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A groundbreaking study has revealed new insights into the structure of synapses using advanced imaging techniques. Researchers discovered that astrocytes, star-shaped glial cells in the brain, play a crucial role in synaptic function by tightly interacting with synapses. This interaction is essential for maintaining healthy brain communication. In mouse models of Huntington’s disease, astrocytes failed to properly engage with synapses, leading to leaks of potassium and glutamate, which could disrupt normal brain function. This research highlights the potential of targeting astrocytes in treating neurodegenerative diseases and improves our understanding of the cellular mechanisms underlying these conditions.
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