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During fire accidents, 2 highly toxic components of fire smoke, carbon monoxide (CO) and hydrogen cyanide (HCN), are produced simultaneously, and more than 50% of fire-related deaths can be attributed to the inhalation of these toxic gases. Despite the different CO and HCN detoxification mechanisms, oxygen (O2) ventilation is currently the primary clinical treatment, and no alternative methods are available at present. In this review, the toxicological mechanisms of CO and HCN are investigated with an emphasis on the toxic effects of their combination. On the basis of these toxic mechanisms, the advantages and disadvantages of the current clinical detoxification methods are analyzed and discussed. We also summarize the latest advancements in the development of CO- and HCN-scavenging antidotes, highlighting the strategy of using synthetic iron porphyrins that have been synthesized mainly in our laboratory as water-soluble synthetic hemoglobin biomimetics.
在火灾事故中,同时产生了2种高毒性成分的火灾烟雾,一氧化碳 (CO) 和氰化氢 (HCN),超过50% 的与火灾有关的死亡可归因于吸入这些有毒气体。尽管CO和HCN解毒机制不同,但氧气 (O2) 通气目前是主要的临床治疗方法,目前尚无替代方法。在这篇评论中
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